Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology

Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus - Background: Severe acute respiratory syndrome (SARS) emerged in China in 2002 and spread to other countries before brought under control. Because of a concern for reemergence or a deliberate release of the SARS coronavirus, vaccine development was initiated. Evaluations of an inactivated whole virus vaccine in ferrets and nonhuman primates and a virus-like-particle vaccine in mice induced protection against infection but challenged animals exhibited an immunopathologic-type lung disease.

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